Medicating Bipolar Disorder: Recent Advances
Although this comes as no surprise to me, there is now clear evidence that lithium is the most efficacious single agent for managing bipolar mania and bipolar depression. If, for whatever reason, lithium is not effective as monotherapy, combining Depakote with it does increase efficacy – although not markedly. The lithium/Depakote combination therefore is optimal in the treatment of bipolar mania. It is becoming increasingly more evident that traditional antidepressants (cyclics, SSRIs, SNRIs, Atypicals) have little, if any advantage, in [...]